Drug shortage is a challenge beyond regional borders. It has become a global issue since 2011. Based on the facts of high quality talents, relatively lower labor costs and modern automated factories, Taiwan can provide higher quality generic drugs when the drugs are in short supply. Of all the drugs that are used in the National Health Insurance scheme, 75% are supplied by local manufacturers. More than half of Taiwan pharmaceuticals can swim the tide. It proves that Taiwan pharmaceuticals can do their part for supplying high quality drugs and make changes to the drug shortage issues.